Publications

Nauš, P.; Caletková, O.; Perlíková, P.; Slavětínská, L. Poštová; Tloušťová, E.; Hodek, J.; Weber, J.; Džubák, P.; Hajdúch, M.; Hocek, M. Synthesis and biological profiling of 6- or 7-(het)aryl-7-deazapurine 4′-C-methylribonucleosides. Bioorganic & Medicinal Chemistry 2015, 23 (23), 7422-7438 DOI: 10.1016/j.bmc.2015.10.040.

Tichý, M.; Pohl, R.; Tloušt’ová, E.; Weber, J.; Bahador, G.; Lee, Y. - J.; Hocek, M. Synthesis and biological activity of benzo-fused 7-deazaadenosine analogues. 5- and 6-substituted 4-amino- or 4-alkylpyrimido[4,5-b]indole ribonucleosides. Bioorganic & Medicinal Chemistry 2013, 21 (17), 5362-5372 DOI: 10.1016/j.bmc.2013.06.011.

Tichý, M.; Pohl, R.; Xu, H. Ying; Chen, Y. - L.; Yokokawa, F.; Shi, P. - Y.; Hocek, M. Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides. Bioorganic & Medicinal Chemistry 2012, 20 (20), 6123-6133 DOI: 10.1016/j.bmc.2012.08.021.

Nauš, P.; Perlíková, P.; Bourderioux, A.; Pohl, R.; Slavětínská, L.; Votruba, I.; Bahador, G.; Birkuš, G.; Cihlář, T.; Hocek, M. Sugar-modified derivatives of cytostatic 7-(het)aryl-7-deazaadenosines: 2′-C-methylribonucleosides, 2′-deoxy-2′-fluoroarabinonucleosides, arabinonucleosides and 2′-deoxyribonucleosides. Bioorganic & Medicinal Chemistry 2012, 20 (17), 5202-5214 DOI: 10.1016/j.bmc.2012.07.003.

Snášel, J.; Nauš, P.; Dostál, J.; Hnízda, A.; Fanfrlík, J.; Brynda, J.; Bourderioux, A.; Dušek, M.; Dvořáková, H.; Stolaříková, J.; et al. Structural Basis for Inhibition of Mycobacterial and Human Adenosine Kinase by 7-Substituted 7-(Het)aryl-7-deazaadenine Ribonucleosides. Journal of Medicinal Chemistry 2014, 57 (20), 8268-8279 DOI: 10.1021/jm500497v.

Ivancova, I.; Pohl, R.; Hubalek, M.; Hocek, M. Squaramate-Modified Nucleotides and DNA for Specific Cross-Linking with Lysine-Containing Peptides and Proteins. Angewandte Chemie-International Edition 2019, 58 (38), 13345-13348 DOI: 10.1002/anie.201906737.

Bobula, T.; Hocek, M.; Kotora, M. Sonogashira reactions of α- and β-1-ethynyl-2-deoxyribosides: synthesis of acetylene-extended C-nucleosides. Tetrahedron 2010, 66 (2), 530-536 DOI: 10.1016/j.tet.2009.11.030.

Dziuba, D.; Pospíšil, P.; Matyašovský, J.; Brynda, J.; Nachtigallová, D.; Rulíšek, L.; Pohl, R.; Hof, M.; Hocek, M. Solvatochromic fluorene-linked nucleoside and DNA as color-changing fluorescent probes for sensing interactions. Chem. Sci. 2016, 7 (9), 5775-5785 DOI: 10.1039/C6SC02548J.

Ménová, P.; Raindlová, V.; Hocek, M. Scope and Limitations of the Nicking Enzyme Amplification Reaction for the Synthesis of Base-Modified Oligonucleotides and Primers for PCR. Bioconjugate Chemistry 2013, 24 (6), 1081-1093 DOI: 10.1021/bc400149q.

Dziuba, D.; Jurkiewicz, P.; Cebecauer, M.; Hof, M.; Hocek, M. A Rotational BODIPY Nucleotide: An Environment-Sensitive Fluorescence-Lifetime Probe for DNA Interactions and Applications in Live-Cell Microscopy. Angewandte Chemie International Edition 2016, 55 (1), 174-178 DOI: 10.1002/anie.201507922.

Džubák, P.; Gurska, S.; Hajdúch, M.; Hocek, M.; Pohl, R.; Tloušťová, E.; Veselovská, L. Pyrido-Fused Deazapurine Bases: Synthesis and Glycosylation of 4-Substituted 9H-Pyrido[2',3':4,5]- and Pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidines. ACS Omega [online] 2020, 5 (40), 26278-26286 DOI: 10.1021/acsomega.0c04302.

Ménová, P.; Hocek, M. Preparation of short cytosine-modified oligonucleotides by nicking enzyme amplification reaction. Chemical Communications 2012, 48 (55), 6921 DOI: 10.1039/c2cc32930a.

Vaníková, Z.; Hocek, M. Polymerase Synthesis of Photocaged DNA Resistant against Cleavage by Restriction Endonucleases. Angewandte Chemie International Edition 2014, 53 (26), 6734-6737 DOI: 10.1002/anie.201402370.

Ménová, P.; Cahová, H.; Plucnara, M.; Havran, L.; Fojta, M.; Hocek, M. Polymerase synthesis of oligonucleotides containing a single chemically modified nucleobase for site-specific redox labelling. Chemical Communications 2013, 49 (41), 4652 DOI: 10.1039/c3cc41438h.

Mačková, M.; Pohl, R.; Hocek, M. Polymerase Synthesis of DNAs Bearing Vinyl Groups in the Major Groove and their Cleavage by Restriction Endonucleases. ChemBioChem 2014, 15 (15), 2306-2312 DOI: 10.1002/cbic.201402319.

Dziuba, D.; Pohl, R.; Hocek, M. Polymerase synthesis of DNA labelled with benzylidene cyanoacetamide-based fluorescent molecular rotors: fluorescent light-up probes for DNA-binding proteins. Chem. Commun. 2015, 51 (23), 4880-4882 DOI: 10.1039/C5CC00530B.

Nakatani, K.; Tor, Y.; Dadová, J.; Cahová, H.; Hocek, M. Polymerase Synthesis of Base-Modified DNA; Springer International Publishing: Cham, 2016; Vol. 31, pp 123-144.

Mačková, M.; Boháčová, S.; Perlíková, P.; Slavětínská, L. Poštová; Hocek, M. Polymerase Synthesis and Restriction Enzyme Cleavage of DNA Containing 7-Substituted 7-Deazaguanine Nucleobases. ChemBioChem 2015, 16 (15), 2225-2236 DOI: 10.1002/cbic.201500315.

Hausnerova, V. Vankova; Hocek, M.; Chakrapani, A.; Krásný, L.; Pohl, R.; Ruiz-Larrabeiti, O. Photocaged 5-(Hydroxymethyl)pyrimidine Nucleoside Phosphoramidites for Specific Photoactivatable Epigenetic Labeling of DNA. Organic Letters 2020, 22 (22), 9081-9085 DOI: 10.1021/acs.orglett.0c03462.

Brown, T.; El-Sagheer, A. H.; Hocek, M.; Kellett, A.; Panattoni, A. Oxidative DNA Cleavage with Clip-Phenanthroline Triplex-Forming Oligonucleotide Hybrids. Chembiochem : a European journal of chemical biology 2020, 21 (7), 991-1000 DOI: 10.1002/cbic.201900670.

Kielkowski, P.; Brock, N. L.; Dickschat, J. S.; Hocek, M. Nucleobase Protection Strategy for Gene Cloning and Expression. ChemBioChem 2013, 14 (7), 801-804 DOI: 10.1002/cbic.201300127.

Nečas, D.; Hidasová, D.; Hocek, M.; Kotora, M. Modular synthesis of 1-α- and 1-β-(indol-2-yl)-2′-deoxyribose C-nucleosides. Organic & Biomolecular Chemistry 2011, 9 (17), 5934 DOI: 10.1039/c1ob05844d.

Klečka, M.; Slavětínská, L. Poštová; Hocek, M. Modification of Pyrrolo[2,3-d]pyrimidines by C-H Borylation Followed by Cross-Coupling or Other Transformations: Synthesis of 6,8-Disubstituted 7-Deazapurine Bases. European Journal of Organic Chemistry 2015, 2015 (36), 7943-7961 DOI: 10.1002/ejoc.201501177.

Simonova, A.; Balintová, J.; Pohl, R.; Havran, L.; Fojta, M.; Hocek, M. Methoxyphenol and Dihydrobenzofuran as Oxidizable Labels for Electrochemical Detection of DNA. ChemPlusChem 2014, n/a-n/a DOI: 10.1002/cplu.201402194.

Riedl, J.; Pohl, R.; Ernsting, N. P.; Orság, P.; Fojta, M.; Hocek, M. Labelling of nucleosides and oligonucleotides by solvatochromic 4-aminophthalimide fluorophore for studying DNA–protein interactions. Chemical Science 2012, 3 (9), 2797 DOI: 10.1039/c2sc20404e.