We are currently working on following research projects:
Enantioselective construction of quaternary carbon centres
All-carbon quaternary centres occur widely in natural products as well as pharmaceutically important compounds. Their preparation in an enantioselective fashion, however, still represents one of the greatest challenges in synthetic organic chemistry. This project deals with asymmetric formation of quaternary centres and its possible application in the synthesis of biologically active compounds and/or fenestranes. Our main focus is on using tandem cyclisation/Suzuki cross-coupling and subsequent halocarbocyclisation reaction sequence as a new method to achieve this goal. We would like to apply this method for the preparation of biologically active natural products, such as crinine- and haemanthamine-type Amaryllidaceae alkaloids and other structurally related compounds.