Publications | Group of Organometallic and Synthetic Chemistry

22. Synthesis and Structural Confirmation of Selaginpulvilin X

T. Havlíková, S. Nallappan, I Císařová, L. Rycek

Org. Biomol. Chem., 2024, 10.1039/D4OB01529K

21. Selagibenzophenone B and Its Derivatives: SelB-1, a Dual Topoisomerase I/II Inhibitor Identified through In Vitro and In Silico Analyses

S. Dönmez, R. Lapinskaite, H. N. Atalay, E. Tokay, F. Kockar, L. Rycek*, M. Özbil*, T. B. Tumer*

ACS Bio & Med Chem Au, 2024, 4, 178–189. 10.1021/acsbiomedchemau.4c00027

20. Silver Complex Bearing N-Heterocyclic Carbene Bidentate Chelating Ligand as an Efficient Catalyst in Solvent-Free KA2 Coupling

M. Mateus, L. Rycek

ChemPlusChem, 2024, e202400365. 10.1002/cplu.202400365

19. Internal 2D networking of silver bromide with a bidentate N-heterocyclic carbene ligand enables the formation of an inherently heterogeneous reusable catalyst for multicomponent A3 coupling.

S. Nallappan, O. Kucherak, A. Kiss, R. Lapinskaite, I. Císařová, L. Rycek

New. J. Chem., 2024, 48, 12800-12806. 10.1039/d4nj02010c

Graphical abstract: Internal 2D networking of silver bromide with a bidentate N-heterocyclic carbene ligand enables the formation of an inherently heterogeneous reusable catalyst for multicomponent A3 coupling

18. The Biomimetic Synthesis of Polyarylated Fluorenes, Relevant to Selaginellaceae Polyphenols, Leading to the Spontaneous Formation of Stable Radicals.

S. Nallappan, R. Lapinskaite, J. Hájíček, D. Kunák, P. Čambal, D. Nečas, I. Císařová, H. N. Atalay, T. B. Tumer, J. Tarábek, K. Schwarzová-Pecková, L. Rycek

ChemPlusChem, 2024, 89, e202300410. 10.1002/cplu.202300410

17. Synthesis of Selagibenzophenone A and Its Derivatives for Evaluation of Their Antiproliferative, RORγ Inverse Agonistic, and Antimicrobial Effect

R. Lapinskaite, H. N. Atalay, Š. Malatinec, S. Donmez, Z. O. Cinar, P. F. Schwarz, A. F. Perhal, I. Císařová, L. Labanauskas, T. M. Karpiński, V. M. Dirsch, T. B. Tumer, L. Rycek

ChemistrySelect, 2023, 10.1002/slct.202204816

16. Synthesis of Silver Complexes with Chelating Bidentate N-Heterocyclic Ligands, their Application in Catalytic A3 Coupling and as Antimicrobial Agents

M. Mateus, A. Kiss, I. Císařová, Tomasz M. Karpiński, L. Rycek

Appl. Organomet. Chem. 2023, 37, e6994.

15. Totální syntéza přírodních látek: případové studie pro zhodnocení nových syntetických metod, objasnění strukturních aspektů a vývoj léčiv.

(Total Synthesis of Natural Products: Case Studies in the Evaluation of New Synthetic Methods, Structural Elucidation and Drug Discovery)

L. Rycek

Chemické Listy 2022, 116, 204-2014.

14. Synthesis and Structure Confirmation of Selagibenzophenone C.

D. Kunák, M. Mateus, L. Rycek

Eur. J. Org. Chem. 2022 10.1002/ejoc.202200014

13. Cross-Coupling as a Key Step in the Synthesis and Structure Revision of the Natural Products Selagibenzophenones A and B.

R. Lapinskaite, Š. Malatinec, M. Mateus, L. Rycek

Catalysts 2021, 11(6), 708; https://doi.org/10.3390/catal11060708

12. Catalytic Cyclotrimerization Pathway for Synthesis of Selaginpulvilins C and D: Scope and Limitations.

L. Rycek, M. Mateus, N. Beytrlerová, M. Kotora

Org. Lett. 2021, 23, 4511-4515.

11. Tetrodotoxin: History, Biology, and Synthesis

M. Makarova, L. Rycek, J. Hajicek, D. Baidilov, T. Hudlicky

Angew. Chem. Int. Ed. 2019, 59, 18338-18387.

10. Stereoselective Synthesis of Notoincisol A Isomers and their Biological Evaluation on GABA_A receptors and PPARg Receptors

L. Rycek, V. Ticli, J. Pyszkowski, S. Lacotnik, A. Atanasov, V. Dirsh, M. Schnürch, M. Ernst, M. D. Mihovilovic

J. Nat. Prod. 2018, 81, 2419-2428.

9. Preparation of Rearranged Allylic Isocyanates from the Reaction of Allylic Alcohols with 1-Cyano-4-dimethylaminopyridinium Bromide

D. Baidilov, M. Makarova, L. Rycek, T. Hudlicky,

Synthesis, 2018, 50, 4606-4610.

8. Magnolol dimer-derived fragments as PPARγ-selective probes

D. Dreier, M. Resetar, V. Temml, L. Rycek, N. Kratena, M. Schnürch, D. Schuster, V. M. Dirsch and M. D. Mihovilovic

Org. Biomol. Chem. 2018, 16, 7019-7028.

7. Chemoenzymatic Synthesis of Advanced Intermediates for Formal Total Syntheses of Tetrodotoxin

D. Baidilov, L. Rycek, J. F. Trant, J. Froese, B. Murphy, T. Hudlický

Angew. Chem. Int. Ed. 2018, 57, 10994-10998.

6. Linked magnolol dimer as a selective PPARγ agonist – Structure-based rational design, synthesis, and bioactivity evaluation

D. Dreier, S. Latkolik, L. Rycek, M. Schnürch, A. Dymáková, A. G. Atanasov, A. Ladurner, E. H. Heiss, H. Stuppner, D. Schuster, M. D. Mihovilovic, V. M. Dirsch

Scientific Reports 2017, 7, 13002.

5. Applications of Still rearrangement in organic synthesis

L. Rycek, T. Hudlický

Angew. Chem. Int. Ed. 2017, 56, 6022-6066.

4. Chemoenzymatic total synthesis of hydromorphone by an oxidative dearomatization/intramolecular [4+2] cycloaddition sequence: a 2nd generation approach

L. Rycek, J. J. Hayward, M. A. Latif, J. Tanko, R. Simionescu, T. Hudlický

J. Org. Chem. 2016, 81, 10930–10941.

3. Metal catalyzed cross-coupling reactions in the decoration of pyrimidine, pyridazine, and pyrazine

L. Wimmer, L. Rycek, M. Koley, M. Schnürch

2016, In Patonay Tomás, Krisztina Kónya (eds.), Topics in Heterocyclic chemistry: Synthesis and Modification of Heterocycles by Metal Catalyzed Cross-coupling Reactions (pp.61-158), Switzerland, Springer.

2. Metal-Assisted Synthesis of Unsymmetrical Magnolol Analogs and their Biological Assessment as GABAA Receptor Ligands

L. Rycek, R. Puthenkalam, M. Schnürch, M. Ernst, M. D. Mihovilovic

Bioorg. Med. Chem. Lett. 2015, 25, 400-403.

1. Synthesis of 4-Aminoquinazolines by Palladium-Catalyzed Intramolecular Imidoylation of N-(2-Bromoaryl)amidines

G. Van Baelen, S. Kuijer, L. Rýček, S. Sergeyev, E. Janssen, F. J. J. de Kanter, B. U. W. Maes, E. Ruijter and R. V. A. Orru

Eur. J. Chem. 2011, 17, 15039-15044.