Publications

Kocek, H.; Chalupská, D.; Dejmek, M.; Dvořáková, A.; Zgarbová, M.; Šála, M.; Chalupský, K.; Krafčíková, P.; Otava, T.; Drexler, M.; et al. Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5′-carboxamides. RSC Medicinal Chemistry 2024, nestránkováno.

Kočková, O.; Kasal, P.; Zelený, J.; Walterova, Z.; Vlčková, V.; Jindřich, J. Effect of Counterions on the Soft Ionization Mass Spectra of Analytes with Multiple Permanent Charges. Analytical Chemistry 2024, 96 (18), 6940-6946.

Veselý, O.; Živný, M.; Nigríni, M.; Veselý, J.; Čejka, J. The effect of the active site and substrate structure in preparation of substituted tetrahydropyrans via intramolecular cyclization. Catalysis Today 2024, 429 (March).

Tóth, L. Julianna; Krejčová, K.; Dejmek, M.; Žilecká, E.; Klepetářová, B.; Slavětínská, L. Poštová; Bouřa, E.; Nencka, R. Novel analogues of a nonnucleoside SARS-CoV-2 RdRp inhibitor as potential antivirotics. Beilstein Journal of Organic Chemistry 2024, 20 (MAY 6 2024), 1029-1036.

Štefek, M.; Chalupská, D.; Chalupský, K.; Zgarbová, M.; Dvořáková, A.; Krafčíková, P.; Li, A. Shi Ming; Šála, M.; Dejmek, M.; Otava, T.; et al. Rational Design of Highly Potent SARS-CoV-2 nsp14 Methyltransferase Inhibitors. ACS Omega 2023, 8 (30), 27410-27418.

Ziabko, M.; Klepetářová, B.; Beier, P. Synthesis of Azidodifluoromethyl Phenyl Sulfone and Its Use as a Synthetic Equivalent of the Azidodifluoromethyl Anion. Journal of Organic Chemistry 2023, 88 (11), 6939-6946.

Baszczyňski, O.; Černý, J.; Čmoková, A.; Grobárová, V.; Kolařík, M.; Procházková, E.; Slapničková, M.; Štěpánek, O.; Zíková, A. Piperazine-Modified Ketoconazole Derivatives Show Increased Activity against Fungal and Trypanosomatid Pathogens. ChemMedChem 2022, 17 (21), nestránkováno.

Baszczyňski, O.; Dračínský, M.; Dvořáková, A.; Hodek, J.; Chalupský, K.; Janeba, Z.; Kalčic, F.; Kaiserová, H. Mertlíkov; Strmeň, T.; Šebestík, J.; et al. Discovery of Modified Amidate (ProTide) Prodrugs of Tenofovir with Enhanced Antiviral Properties. Journal of Medicinal Chemistry 2021, 64 (22), 16425-16449.

Kamlar, M.; Sunden, H.; Zacharias, S. C. Exploring Supramolecular Gels in Flow-Type Chemistry-Design and Preparation of Stationary Phases. Industrial and Engineering Chemistry Research 2021, 60 (28), 10056-10063.

Doleželová, E.; Downey, A. Michael; Hocek, M.; Nguyen, V. Hai; Pohl, R.; Rožánková, S.; Slapničková, M.; Tichý, M.; Tloušťová, E.; Zíková, A. Synthesis and anti-trypanosomal activity of 3'-fluororibonucleosides derived from 7-deazapurine nucleosides. Bioorganic and Medicinal Chemistry Letters 2021, 40 (May 15 2021), nestránkováno.

Doleželová, E.; Džubák, P.; Gurská, S.; Hajdúch, M.; Hocek, M.; Krajczyk, A.; Milisavljević, N.; Perlíková, P.; Slavětínská, L. Poštová; Slapničková, M.; et al. Synthesis and Antitrypanosomal Activity of 6-Substituted 7-Methyl-7-deazapurine Nucleosides. ACS Infectious Diseases 2021, 7 (4), 917-926.

Gálisová, A.; Groborz, O.; Hájek, M.; Hrubý, M.; Jirák, D.; Kolouchová, K.; Sedláček, O.; Sticová, E.; Švec, P.; Trousil, J.; et al. Implant-forming polymeric 19F MRI-tracer with tunable dissolution. Journal of Controlled Release 2020, 327 (November), 50-60 DOI: 10.1016/j.jconrel.2020.07.026.

Anania, M.; Jašík, J.; Jašíková, L.; Roithová, J.; Shcherbachenko, E.; Zelenka, J. Monoaurated vs. diaurated intermediates: causality or independence?. Chemical Science 2020, 11 (4), 980-988 DOI: 10.1039/c9sc05662a.

Albiñana, C. Berenguer; Brynda, J.; Fanfrlík, J.; Flieger, M.; Hodek, J.; Karlukova, E.; Konvalinka, J.; Kožíšek, M.; Machara, A.; Majer, P.; et al. Unraveling the anti-influenza effect of flavonoids: Experimental validation of luteolin and its congeners as potent influenza endonuclease inhibitors. European Journal of Medicinal Chemistry 2020, 208 (December), nestránkováno DOI: 10.1016/j.ejmech.2020.112754.

Güixens-Gallardo, P.; Zawada, Z.; Matyašovský, J.; Dziuba, D.; Pohl, R.; Kraus, T.; Hocek, M. Brightly Fluorescent 2 '-Deoxyribonucleoside Triphosphates Bearing Methylated Bodipy Fluorophore for in Cellulo Incorporation to DNA, Imaging, and Flow Cytometry. Bioconjugate Chemistry 2018, 29 (11), 3906-3912 DOI: 10.1021/acs.bioconjchem.8b00721.

Zhang, K.; Meazza, M.; Docekal, V.; Light, M. E.; Vesely, J.; Rios, R. Highly Diastereo- and Enantioselective Synthesis of alpha-Spiro-delta-lactams by an Organocascade Reaction. European Journal of Organic Chemistry 2017, No. 13, 1749-1756 DOI: 10.1002/ejoc.201700193.

Perlikova, P.; Rylova, G.; Naus, P.; Elbert, T.; Tloustova, E.; Bourderioux, A.; Slavetinska, L. P.; Motyka, K.; Dolezal, D.; Znojek, P.; et al. 7-(2-Thienyl)-7-Deazaadenosine (AB61), a New Potent Nucleoside Cytostatic with a Complex Mode of Action. Molecular Cancer Therapeutics 2016, 15 (5), 922-937 DOI: 10.1158/1535-7163.MCT-14-0933.

Tumova, L.; Pombinho, A. R.; Vojtechova, M.; Stancikova, J.; Gradl, D.; Krausova, M.; Sloncova, E.; Horazna, M.; Kriz, V.; Machonova, O.; et al. Monensin inhibits canonical wnt signaling in human colorectal cancer cells and suppresses tumor growth in multiple intestinal neoplasia mice. Molecular cancer therapeutics 2014, 13 (4), 812-822 DOI: 10.1158/1535-7163.MCT-13-0625.

Snášel, J.; Nauš, P.; Dostál, J.; Hnízda, A.; Fanfrlík, J.; Brynda, J.; Bourderioux, A.; Dušek, M.; Dvořáková, H.; Stolaříková, J.; et al. Structural Basis for Inhibition of Mycobacterial and Human Adenosine Kinase by 7-Substituted 7-(Het)aryl-7-deazaadenine Ribonucleosides. Journal of Medicinal Chemistry 2014, 57 (20), 8268-8279 DOI: 10.1021/jm500497v.

Malkov, A. V.; Ramírez-López, P.; Bendová), L. Biedermann; Rulíšek, L.; Dufková, L.; Kotora, M.; Zhu, F.; Kočovský, P. On the mechanism of asymmetric allylation of aldehydes with allyltrichlorosi lanes catalyzed by QUINOX, a chiral lsoquinoline N-oxide. Journal of the American Chemical Society 2008, 130 (15), 5341-5348 DOI: 10.1021/ja711338q.