Publications

Found 91 results
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2013
Tichý, M.; Pohl, R.; Tloušt’ová, E.; Weber, J.; Bahador, G.; Lee, Y. - J.; Hocek, M. Synthesis and biological activity of benzo-fused 7-deazaadenosine analogues. 5- and 6-substituted 4-amino- or 4-alkylpyrimido[4,5-b]indole ribonucleosides. Bioorganic & Medicinal Chemistry 2013, 21 (17), 5362-5372 DOI: 10.1016/j.bmc.2013.06.011.
Perlíková, P.; Eberlin, L.; Ménová, P.; Raindlová, V.; Slavětínská, L.; Tloušťová, E.; Bahador, G.; Lee, Y. - J.; Hocek, M. Synthesis and Cytostatic and Antiviral Activities of 2′-Deoxy-2′,2′-difluororibo- and 2′-Deoxy-2′-fluororibonucleosides Derived from 7-(Het)aryl-7-deazaadenines. ChemMedChem 2013, 8 (5), 832-846 DOI: 10.1002/cmdc.201300047.
Kubelka, T.; Slavětínská, L.; Eigner, V.; Hocek, M. Synthesis of 2,6-disubstituted pyridin-3-yl C-2′-deoxyribonucleosides through chemoselective transformations of bromo-chloropyridine C-nucleosides. Organic & Biomolecular Chemistry 2013, 11 (28), 4702 DOI: 10.1039/c3ob40774h.
Kalachova, L.; Pohl, R.; Bednárová, L.; Fanfrlík, J.; Hocek, M. Synthesis of nucleosides and dNTPs bearing oligopyridine ligands linked through an octadiyne tether, their incorporation into DNA and complexation with transition metal cations. Org. Biomol. Chem. 2013, 11 (1), 78-89 DOI: 10.1039/C2OB26881G.
Dadová, J.; Orság, P.; Pohl, R.; Brázdová, M.; Fojta, M.; Hocek, M. Vinylsulfonamide and Acrylamide Modification of DNA for Cross-linking with Proteins. Angewandte Chemie International Edition 2013, 52 (40), 10515-10518 DOI: 10.1002/anie.201303577.
2014
Kielkowski, P.; Fanfrlík, J.; Hocek, M. 7-Aryl-7-deazaadenine 2′-Deoxyribonucleoside Triphosphates (dNTPs): Better Substrates for DNA Polymerases than dATP in Competitive Incorporations. Angewandte Chemie International Edition 2014, 53 (29), 7552-7555 DOI: 10.1002/anie.201404742.
Dziuba, D.; Pohl, R.; Hocek, M. Bodipy-Labeled Nucleoside Triphosphates for Polymerase Synthesis of Fluorescent DNA. Bioconjugate Chemistry 2014, 25 (11), 1984-1995 DOI: 10.1021/bc5003554.
Hocek, M.; Ćerňová, M.; Pohl, R.; Klepetářová, B. C-H Trifluoromethylations of 1,3-Dimethyluracil and Reactivity of the Products in C-H Arylations. HETEROCYCLES 2014, 89 (5), 1159 DOI: 10.3987/COM-14-12958.
Krömer, M.; Klečka, M.; Slavětínská, L.; Klepetářová, B.; Hocek, M. Chemoselective Synthesis of 4,5-Diarylpyrrolo[2,3-d]pyrimidines (6,7-Diaryl-7-deazapurines) by Consecutive Suzuki and Liebeskind-Srogl Cross-Couplings. European Journal of Organic Chemistry 2014, 2014 (32), 7203-7210 DOI: 10.1002/ejoc.201402882.
Sabat, N.; Klečka, M.; Slavětínská, L.; Klepetářová, B.; Hocek, M. Direct C-H amination and C-H chloroamination of 7-deazapurines. RSC Adv. 2014 DOI: 10.1039/C4RA13143F.
Danhel, A.; Raindlová, V.; Havran, L.; Pivonkova, H.; Hocek, M.; Fojta, M. Electrochemical behaviour of 2,4-dinitrophenylhydrazi(o)ne as multi-redox centre DNA label at mercury meniscus modified silver solid amalgam electrode. Electrochimica Acta 2014, 126, 122-131 DOI: 10.1016/j.electacta.2013.09.147.
Simonova, A.; Balintová, J.; Pohl, R.; Havran, L.; Fojta, M.; Hocek, M. Methoxyphenol and Dihydrobenzofuran as Oxidizable Labels for Electrochemical Detection of DNA. ChemPlusChem 2014, n/a-n/a DOI: 10.1002/cplu.201402194.
Mačková, M.; Pohl, R.; Hocek, M. Polymerase Synthesis of DNAs Bearing Vinyl Groups in the Major Groove and their Cleavage by Restriction Endonucleases. ChemBioChem 2014, 15 (15), 2306-2312 DOI: 10.1002/cbic.201402319.
Vaníková, Z.; Hocek, M. Polymerase Synthesis of Photocaged DNA Resistant against Cleavage by Restriction Endonucleases. Angewandte Chemie International Edition 2014, 53 (26), 6734-6737 DOI: 10.1002/anie.201402370.
Snášel, J.; Nauš, P.; Dostál, J.; Hnízda, A.; Fanfrlík, J.; Brynda, J.; Bourderioux, A.; Dušek, M.; Dvořáková, H.; Stolaříková, J.; et al. Structural Basis for Inhibition of Mycobacterial and Human Adenosine Kinase by 7-Substituted 7-(Het)aryl-7-deazaadenine Ribonucleosides. Journal of Medicinal Chemistry 2014, 57 (20), 8268-8279 DOI: 10.1021/jm500497v.
Nauš, P.; Caletková, O.; Konečný, P.; Džubák, P.; Bogdanová, K.; Kolář, M.; Vrbková, J.; Slavětínská, L.; Tloušt’ová, E.; Perlíková, P.; et al. Synthesis, Cytostatic, Antimicrobial, and Anti-HCV Activity of 6-Substituted 7-(Het)aryl-7-deazapurine Ribonucleosides. Journal of Medicinal Chemistry 2014, 57 (3), 1097-1110 DOI: 10.1021/jm4018948.
Hocek, M. Synthesis of Base-Modified 2′-Deoxyribonucleoside Triphosphates and Their Use in Enzymatic Synthesis of Modified DNA for Applications in Bioanalysis and Chemical Biology. The Journal of Organic Chemistry 2014, 79 (21), 9914-9921 DOI: 10.1021/jo5020799.
Danhel, A.; Raindlová, V.; Havran, L.; Barek, J.; Hocek, M.; Fojta, M. Voltammetric Study of dsDNA Modified by Multi-redox Label Based on N-methyl-4-hydrazino-7-nitrobenzofurazan. Electrochimica Acta 2014, 129, 348-357 DOI: 10.1016/j.electacta.2014.02.137.
2015
Malnuit, V.; Slavětínská, L. Poštová; Nauš, P.; Džubák, P.; Hajdúch, M.; Stolaříková, J.; Snášel, J.; Pichová, I.; Hocek, M. 2-Substituted 6-(Het)aryl-7-deazapurine Ribonucleosides: Synthesis, Inhibition of Adenosine Kinases, and Antimycobacterial Activity. ChemMedChem 2015, 10 (6), 1079-1093 DOI: 10.1002/cmdc.201500081.
Balintová, J.; Špaček, J.; Pohl, R.; Brázdová, M.; Havran, L.; Fojta, M.; Hocek, M. Azidophenyl as a click-transformable redox label of DNA suitable for electrochemical detection of DNA–protein interactions. Chem. Sci. 2015, 6 (1), 575-587 DOI: 10.1039/C4SC01906G.
Dadová, J.; Vrábel, M.; Adámik, M.; Brázdová, M.; Pohl, R.; Fojta, M.; Hocek, M. Azidopropylvinylsulfonamide as a New Bifunctional Click Reagent for Bioorthogonal Conjugations: Application for DNA-Protein Cross-Linking. Chemistry - A European Journal 2015, 21 (45), 16091-16102 DOI: 10.1002/chem.201502209.
Olszewska, A.; Dadová, J.; Mačková, M.; Hocek, M. Cleavage of DNA containing 5-fluorocytosine or 5-fluorouracil by type II restriction endonucleases. Bioorganic & Medicinal Chemistry 2015, 23 (21), 6885-6890 DOI: 10.1016/j.bmc.2015.09.051.
A. Downey, M.; Richter, C.; Pohl, R.; Mahrwald, R.; Hocek, M. Direct One-Pot Synthesis of Nucleosides from Unprotected or 5-O-Monoprotected D-Ribose. Organic Letters 2015, 17 (18), 4604-4607 DOI: 10.1021/acs.orglett.5b02332.
Ménová, P.; Dziuba, D.; Güixens-Gallardo, P.; Jurkiewicz, P.; Hof, M.; Hocek, M. Fluorescence Quenching in Oligonucleotides Containing 7-Substituted 7-Deazaguanine Bases Prepared by the Nicking Enzyme Amplification Reaction. Bioconjugate Chemistry 2015, 26 (2), 361-366 DOI: 10.1021/acs.bioconjchem.5b00006.
Sabat, N.; Slavětínská, L. Poštová; Hocek, M. Ir-catalyzed C–H silylations of phenyldeazapurines. Tetrahedron Letters 2015, 56 (49), 6860-6862 DOI: 10.1016/j.tetlet.2015.10.089.
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