Influence of substituent position and cavity size of the regioisomers of monocarboxymethyl-α-, β-, and γ-cyclodextrins on the apparent stability constants of their complexes with both enantiomers of Tröger's base

TitleInfluence of substituent position and cavity size of the regioisomers of monocarboxymethyl-α-, β-, and γ-cyclodextrins on the apparent stability constants of their complexes with both enantiomers of Tröger's base
Publication TypeJournal Article
Year of Publication2016
AuthorsŘezanka P, Řezanková K, Sedláčková H, Mašek J, Rokosová L, Bláhová M, Řezanka M, Jindřich J, Sýkora D, Král V
JournalJournal of Separation Science
Volume39
Issue5
Pagination980 - 985
Date Published2016/03/01/
ISBN Number1615-9314
KeywordsCapillary electrophoresis, Chiral separation, Cyclodextrin, Regioisomers, Stability constants
AbstractEnantiomers of Tröger's base were separated by capillary electrophoresis using 2I-O-, 3I-O-, and 6I-O-carboxymethyl-α-, β-, and γ-cyclodextrin and native α-, β-, and γ-cyclodextrin as chiral additives at 0–12 mmol/L for β-cyclodextrin and its derivatives and 0–50 mmol/L for α- and γ-cyclodextrins and their derivatives in a background electrolyte composed of sodium phosphate buffer at 20 mmol/L concentration and pH 2.5. Apparent stability constants of all cyclodextrin–Tröger's base complexes were calculated based on capillary electrophoresis data. The obtained results showed that the position of the carboxymethyl group as well as the cavity size of the individual cyclodextrin significantly influences the apparent stability constants of cyclodextrin–Tröger's base complexes.
URLhttp://onlinelibrary.wiley.com/doi/10.1002/jssc.201500845/abstract
Short TitleJ. Sep. Science
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